NIMBioS Investigative Workshop:
Modeling Blood Cell Interactions (MBCI)
Topic: Modeling blood cell interactions
Meeting dates: June 5-7, 2013
Damir B. Khismatullin, Dept. of Biomedical Engineering, Tulane Univ., New Orleans, LA
George Em Karniadakis, Division of Applied Mathematics, Brown Univ., Providence, RI
Konstantinos Konstantopoulos, Dept. of Chemical and Biomolecular Engineering, Johns Hopkins Univ., Baltimore, MD
The blood of human and other vertebrates contains a large number of individual, circulating cells. The interactions of these cells with each other and with the internal lining of blood vessels (vascular endothelium) are a key factor in maintaining body homeostasis, including adequate delivery of oxygen to body tissues, protection of the body against invading pathogens and defective cells, and plugging vascular wounds by blood clots. Mathematical modeling of the interactions of blood cells is a challenging, multifaceted, and multi-scale problem that can be appropriately solved only through integration of knowledge across several disciplines such as cell biology, physiology, biophysics, engineering, and mathematics. The Modeling Blood Cell Interactions (MBCI) workshop will bring together experts from these disciplines to share their recent progress in the investigation of blood cell interactions. MBCI will identify future directions in modeling of the collective dynamics of normal and sickle red blood cells, white blood cell-platelet-endothelial cell interactions, hematogenous metastasis of cancer, and activation and migration of adherent leukocytes and tumor cells.
NIMBioS Investigative Workshops focus on broad topics or a set of related topics, summarizing/synthesizing the state of the art and identifying future directions. Organizers and key invited researchers make up half the 30-40 participants in a workshop; the remaining 15-20 participants are filled through open application from the scientific community. Investigative Workshops have the potential for leading to one or more future Working Groups.