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NIMBioS Working Group:

Multiscale Vectored Plant Viruses

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Topic: Multiscale aspects of vector transmission of plant viruses

Meeting dates: December 14-16, 2015; June 22-24, 2016; December 19-23, 2016; December 18-20, 2017

Organizers:
Vrushali A. Bokil, Mathematics, Oregon State Univ., Corvallis
Linda J. S. Allen, Mathematics and Statistics, Texas Tech Univ., Lubbock
Alison Power, Ecology & Evolutionary Biology, Cornell Univ.

Objectives: Plant viruses are one of the greatest limiting factors to modern agriculture. The emergence and evolution of plant viruses impact the health and biodiversity of crops and of plants in general, while the continued growth of the human population emphasizes the need for a sustainable agriculture. The problems in vector transmission of plant viruses are not simple; they are multiscale and often are driven by data from specific crops or fields. Given the multiscale nature of the problems (in both time and space), the necessity of involving multiple variables (hosts and pathogens), and the dependence on environmental variables, multidisciplinary teams with expertise in the biology of plants and viruses and in mathematical methods are needed.

This working group will work on current problems related to multiscale aspects of the spatial and temporal transmission and the evolution of vectored plant viruses. The group's goals are to derive novel mathematical, statistical, and computational methods that incorporate multiple hosts and multiple pathogens operating at varying spatial and temporal scales to bring insight into the effects of climate change and human activities on the emergence of new plant viruses. We will consider some of the most challenging problems in plant disease ecology, to advance the field of vectored plant viruses and provide a better understanding of effective methods for control of plant viral diseases in crops and natural systems.

Ideas for this working group benefited from discussions at the NIMBioS Investigative Workshop on Vectored Plant Diseases, organized by L. J. S. Allen, V. A. Bokil, E. T. Borer, and A. Power, March 17-19, 2014.


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Meeting Summaries


Mtg # Dates Agenda Summary Photo Evaluation
1 Dec 14-16, 2015 pdf Link Link Report
2 Jun 22-24, 2016 pdf Link Link
3 Dec 19-23, 2016 pdf Link Link

Meeting 1 Summary. Several short talks were given on seed degeneration, within-host and between-host models and multiple spatial scales. After brainstorming and extensive discussion, two topics were selected for this first meeting: (1) integrating within-host, between-host models and (2) individual-based and network approaches to address specific biological questions concerning diseases of agricultural importance. Discussions on the first topic led to formulation of a preliminary within-host, between-host model for plant-vector-virus systems with a goal to address cases where explicit vector dynamics or within-host modeling play important roles. Discussions on the second topic led to identification of an agricultural disease of recent origin, maize lethal necrosis (MLN), which is a threat to food security in Sub-Saharan Africa. MLN is incited by coinfection of the Maize chlorotic mottle virus and any of a number of potyviruses. A preliminary outline of a paper and a simple mathematical model for MLN were formulated. The future goals are (1) to continue working on a draft of a paper for MLN with data from Africa to parameterize the model and to compare potential model outcomes from different control scenarios and (2) to update and improve the within-host, between-host model.

Meeting 2 Summary. During the second meeting, progress was made on a model for maize lethal necrosis (MLN), a disease resulting from coinfection of maize crops with Maize chlorotic mottle virus (MCMV) and a potyvirus such as Sugarcane mosaic virus (SCMV). Advice on MLN from an expert external advisor from USDA and data analyses of a single infection versus coinfection with SCMV or MCMV led to further insight into model formulation. A new semi-discrete model with seed, soil and implicit vector transmission was formulated. Extensions of the model and multiscale approaches to plant vectored viruses were discussed and will be investigated in subgroups. The working group decided to focus their immediate efforts on a joint publication on MLN which emphasizes scenarios of interest to localities within Africa and South America, where MLN is an emerging disease. A preliminary working draft of a paper has been outlined and tasks have been assigned to group members to ensure a timely submission of the manuscript for publication.

Meeting 3 Summary. During the third meeting, considerable progress was made toward completion of a manuscript on a coinfection model and its analysis for the spread of maize lethal necrosis (MLN), a disease resulting from coinfection of maize crops with Maize chlorotic mottle virus (MCMV) and a potyvirus such as Sugarcane mosaic virus (SCMV), an emerging plant disease in Kenya. The Working Group focused on management options such as crop rotation, insect control, use of virus-free seed, or removal of infected plants applicable to large commercial farms or to small farms. After subsequent Zoom meetings during January and February 2017, the paper was completed and submitted to the Phytopathology Focus Issue 2017 on Epidemiology: Past, Present and Future Impacts on Understanding Disease Dynamics and Improving Plant Disease Management. This manuscript represents the first modeling papers on MLN. It has now been accepted for publication and is available online.   A press release was distributed by NIMBioS. The group also identified potential topics for a fourth meeting at NIMBioS.

Group photo.
Meeting 1 participants (L to R): Carrie Manore, Alison Power, Karen Garrett, Cherie Briggs, Frederic Hamelin, Megan Rua, Lou Gross, Linda Allen, Frank Hilker, Vrushali Bokil, Nik Cunniffe, Zhilan Feng.

Group photo.
Meeting 2 participants. (Back Row, L to R): Karen Garrett, Alison Power, Frederic Hamelin, Frank Hilker, Linda Allen, Nik Cunniffe, Lou Gross; (Front Row, L to R): Vrushali Bokil, Cherie Briggs, Megan Rua, Carrie Manore.

Group photo.
Meeting 3 participants (L to R): Karen Garrett, Linda Allen, Vrushali Bokil, Frank Hilker, Cherie Briggs, Nik Cunniffe (virtual), Carrie Manore (virtual), Alison Power, Lou Gross, Megan Rua, Frederic Hamelin, Zhilan Feng.
 

NIMBioS Working Groups are chosen to focus on major scientific questions at the interface between biology and mathematics. NIMBioS is particularly interested in questions that integrate diverse fields, require synthesis at multiple scales, and/or make use of or require development of new mathematical/computational approaches. NIMBioS Working Groups are relatively small (up to 10 participants), focus on a well-defined topic, and have well-defined goals and metrics of success. Working Groups will meet up to 3 times over a two-year period, with each meeting lasting up to 2.5 days.

A goal of NIMBioS is to enhance the cadre of researchers capable of interdisciplinary efforts across mathematics and biology. As part of this goal, NIMBioS is committed to promoting diversity in all its activities. Diversity is considered in all its aspects, social and scientific, including gender, ethnicity, scientific field, career stage, geography and type of home institution. Questions regarding diversity issues should be directed to Dr. Ernest Brothers, the NIMBioS Associate Director for Diversity Enhancement (diversity@nimbios.org). You can read more about our Diversity Plan on our NIMBioS Policies web page. The NIMBioS building is fully handicapped accessible.


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NSF logo. NIMBioS is sponsored by the National Science Foundation through NSF Award #DBI-1300426, with additional support from The University of Tennessee, Knoxville. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
 
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