2012 Summer Program, June 11 - August 3, 2012
National Institute for Mathematical and Biological Synthesis (NIMBioS)
at the University of Tennessee, Knoxville
Modeling early evolution of human immunodeficiency virus
Dr. Vitaly Ganusov (Microbiology),
Dr. Calistus Ngonghala (Mathematics)
HIV establishes a life-long chronic infection in vast majority of infected individuals despite strong antiviral responses elicited by the host. High mutation rate of HIV is thought to be one explanation for the ability of the virus to avoid host's immune response yet whether the observed rates of mutation are sufficient to explain rapid appearance of viral variants escaping recognition by T cell immunity is unclear. During this project we will formulate models of HIV evolution and investigate the role of mutation and recombination in early diversification of HIV in patients.
Abstract of project report (PDF)
Return to REU 2012.
1122 Volunteer Blvd., Suite 106
University of Tennessee
PH: (865) 974-9334
FAX: (865) 974-9300
NIMBioS is supported by the
National Science Foundation
through NSF Award #DBI-1300426, with additional support from
The University of Tennessee, Knoxville
. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
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