Title: Modeling early evolution of human immunodeficiency virus
HIV establishes a life-long chronic infection in vast majority of infected individuals despite strong antiviral responses elicited by the host. High mutation rate of HIV is thought to be one explanation for the ability of the virus to avoid host's immune response yet whether the observed rates of mutation are sufficient to explain rapid appearance of viral variants escaping recognition by T cell immunity is unclear. During this project we will formulate models of HIV evolution and investigate the role of mutation and recombination in early diversification of HIV in patients.
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