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Past NIMBioS Postdoctoral Fellow

Clemente Aguilar

C. Aguilar photo. Dates: July 2013 – November 2014
Personal Website
Twitter: @clementeA
Project Title: Prediction and rule inference of MHC class II epitope binder through logic minimization method

As a NIMBioS postdoctoral fellow, Clemente Aguilar (Ph.D. Computational Science/Biology, Univ. of Texas at El Paso, 2013) designed computational methods to identify short fragments of proteins capable of producing and immune response. As the discovery of small molecules is not easy using conventional methods, time and money can be significantly reduced by using computerization. Characterizing molecular fragments has the objective of assisting in the development of vaccines, immunotherapies and diagnostic tools. Upon completing his fellowship at NIMBioS, Dr. Aguilar accepted a position as a postdoctoral fellow in the department of biostatistics at MD Andersen Cancer Center in Houston, TX., working on the application of novel statistical and computational methods for the analysis of complex high-dimensional omics data.

LiveScience Profile Q&A with Dr. Aguilar: Investigating the Molecular Mechanisms of Disease Goes Digital

Video icon. NIMBioS Seminar: Computational characterization of GPI-anchored proteins in Trypanosoma cruzi and their potential use as vaccine candidates

Video Interview: Computation for Chagas

Publications while at NIMBioS

Aguilar-Bonavides C, Sanchez-Arias R, Lanzas C. 2014. Accurate prediction of major histocompatibility complex class II epitopes by spares representation via l1-minimization. BioData Mining, 7:23. [Online]

Aguilar-Bonavides C, Cruz-Cano R, Lanzas C. 2014. Prediction and rule extraction of major histocompatibility complex class II epitopes by logic minimization. Proceedings of the International Conference on Bioinformatics & Computational Biology (BIOCOMP), pp 167-173. The Steering Committee of The World Congress in Computer Science, Computer Engineering and Applied Computing (WorldComp).

Presentations while at NIMBioS

Aguilar C. July 2014. Prediction and rule extraction of major histocompatibility complex class II epitopes by logic minimization. 14th International Conference on Bioinformatics and Computational Biology BIOCOMP'14, Las Vegas, NV.

Collaborations

Carolina Romo, National Institute of Pediatrics, Mexico City. Dr. Romo's lab is investigating the bacterium Helicobacter Pylori, and they are also interested in testing predicted epitopes. Testing with H. pylori was not part of my original NIMBioS proposal, but the algorithms are working with different pathogens. I have predicted the epitopes for this organism, and we are working on the manuscript with the results of the computational prediction.

Alexandre Ferreira Marques, Universidade Federal de Minas Gerais, Brazil. Dr. Margques' lab is interested in testing predicted epitopes from the parasite T. cruzi. To perform the testing, they have infected mice and serum from infected human patients. I have obtained predicted epitopes, and his group is currently testing the predictions.

NIMBioS Working Group/Workshop Participation

NIMBioS Investigative Workshop: Interface Disease Models, March11-13, 2014

NIMBioS Tutorial: Computing in the Cloud, April 6-8, 2014

Education, Outreach and Training

Modern Math Workshop 2014, SACNAS National Conference, October 15-16, 2014. Talk: How to go from digital circuits to vaccine development

Mentored undergraduate students for their participation at the 5th Annual Undergraduate Research Conference at the Interface of Biology and Mathematics, November 16-17, 2013. Poster: "Using bioinformatics to efficiently organize and analyze significant immunogenic epitope sequences in various stages of Trypanosoma cruzi"

Invited speaker, Howard University. Talk: Using computational tools for accelerating the development of vaccines for Chagas disease, November 8, 2013

Completed graduate course, CEM 503: Infectious Disease Modeling, UTK, Fall 2014

Participated in the "Best Practices in Teaching" program offered by the UTK Graduate School, January 22 – March 5, 2014

Attended weekly meetings in Ganusov lab

Regularly attended NIMBioS seminars


Main NIMBioS Postdoc page


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NSF logo. NIMBioS is sponsored by the National Science Foundation through NSF Award #DBI-1300426, with additional support from The University of Tennessee, Knoxville. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
 
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