In conjunction with the interdisciplinary activities of the National Institute for Mathematical and Biological Synthesis (NIMBioS), a seminar series on topics in mathematical biology will be hosted at NIMBioS every other Tuesday at 3:30 p.m. (unless otherwise noted) in the Hallam Auditorium, Room 206, Claxton Building, 1122 Volunteer Blvd. Seminar speakers will focus on their research initiatives at the interface of mathematics and many areas of the life sciences. Light refreshments will be served in Room 206 beginning 30 minutes before each talk. Faculty and students from across the UT community are welcome to join us.
Time/Date: Thursday, August 7, 2014, 2:00 p.m.*
Location: Franklin Classroom, Room 105, Claxton Building, 1122 Volunteer Blvd.
Speaker: Dr. Naveen Vaidya, Mathematics and Statistics, Univ. of Missouri, Kansas City
Topic: Mathematical Modeling of the Within-Host HIV Dynamics
Abstract: The most challenging issues of managing HIV infection within a host are establishment of latently infected cells, emergence of drug resistance, and opioid dependence. In this talk, I will demonstrate how mathematical models that are consistent with experimental data can help address these issues. First, I will show that latently infected cells are largely generated before the initiation of antiretroviral therapy (ART) during early infection and that the density of latently infected cells often decays during initial ART. These results suggest that the latent infection can be limited by early ART during acute HIV infection. Second, I will show that although administration of ART cannot suppress viral load in many patients due to the emergence of resistance, it can alter the viral fitness resulting in an increase of CD4+ T cell count, which should yield clinical benefits. This benefit depends on the cell proliferation rate, which, in some situations, produces sustained T-cell oscillations. Third, I will discuss how opioid dependence can alter viral dynamics, steady state viral load, and basic reproduction number.
*Join us for refreshments at 1:45 p.m.
For more information about this and other NIMBioS Seminars, visit http://www.nimbios.org/seminars.