In conjunction with the interdisciplinary activities of the National Institute for Mathematical and Biological Synthesis (NIMBioS), a seminar series on topics in mathematical biology will be hosted at NIMBioS every other Tuesday at 3:30 p.m. (unless otherwise noted) in the Hallam Auditorium, Room 206, Claxton Building, 1122 Volunteer Blvd. Seminar speakers will focus on their research initiatives at the interface of mathematics and many areas of the life sciences. Light refreshments will be served in Room 205 beginning 30 minutes before each talk. Faculty and students from across the UT community are welcome to join us.
Time/Date: Tuesday, December 2, 2014, 3:30 p.m.*
Location: Room 206, Claxton Building, 1122 Volunteer Blvd.
Speaker: Dr. Ioannis Sgouralis, NIMBioS postdoctoral fellow
Topic: Mathematical modeling of renal complications induced by cardiac surgery
Abstract: Renal hypoxia is an important pathway in the development of acute kidney injury, a common complication of cardiac surgery performed under cardiopulmonary bypass (CPB). In this talk, I will present a mathematical model of kidney's physiology that can be used for the assessment of the conditions promoting renal hypoxia that are observed during CPB. The model represents the fundamentals of a nephrovascular unit: blood flow control, glomerular filtration, and sodium reabsorption. Renal oxygenation is given by the balance of oxygen consumption and oxygen supply, mainly determined by sodium reabsorption and blood flow, respectively. The model is used to simulate the effects of hypotension, hemodilution, and hypothermia. Simulations suggest that the rise in body temperature following the main phase of CPB increases disproportionally medullary oxygen consumption and drives the kidney into a hypoxic state which may result in renal damage.
*Join us for refreshments at 3 p.m. in Room 205.
Seminar Flyer (pdf)
Watch seminar online.
For more information about this and other NIMBioS Seminars, visit http://www.nimbios.org/seminars.