In conjunction with the interdisciplinary activities of the National Institute for Mathematical and Biological Synthesis (NIMBioS), a seminar series on topics in mathematical biology will be hosted at NIMBioS every other Tuesday at 3:30 p.m. (unless otherwise noted) in the Hallam Auditorium, Room 206, Claxton Building, 1122 Volunteer Blvd. Seminar speakers will focus on their research initiatives at the interface of mathematics and many areas of the life sciences. Light refreshments will be served beginning 30 minutes before each talk. Faculty and students from across the UT community are welcome to join us.
Time/Date: Tuesday, September 4, 2012, 3:30 p.m.*
Location: Hallam Auditorium, Room 206, Claxton Building, 1122 Volunteer Blvd
Speaker: Dr. Gesham Magombedze, NIMBioS Postdoctoral Fellow
Topic: Understanding the underlying mechanisms of persistence in mycobacterial infections
Abstract: Mycobacterial infections, such as Mycobacterium avium subspecies paratuberculosis (MAP) which causes Johne's disease in cattle and other ruminants and Mycobacterium tuberculosis (MTB), which is the etiological agent of tuberculosis in humans, are characterized by a persistent and slow infection progression, which can be rapid under certain conditions. Mycobacterial pathogens have the ability to adapt to the changing intracellular environment in response to a dynamic immune response. The underlying mechanisms on how the bacilli can persist irrespective of the host mounting a robust immune response are poorly understood. This talk will: (i) provide insights in understanding some of the MTB bacilli mechanisms associated with its persistence using a mathematical framework that integrates gene expression data and systems biology biochemical systems theory; and (ii) present a mathematical immunological model that helps to understand the cattle immune response mechanisms that are associated with MAP infection progression.
*Join us for refreshments at 3 p.m.
Seminar Flyer (pdf)
For more information about this and other NIMBioS Seminars, visit http://www.nimbios.org/seminars.