In conjunction with the interdisciplinary activities of the National Institute for Mathematical and Biological Synthesis (NIMBioS), a seminar series will be hosted at NIMBioS every other Tuesday at 3:30 p.m. in the NIMBioS Lecture Hall on the 4th floor of 1534 White Ave., Suite 400 Seminar speakers will focus on their research initiatives at the interface of mathematics and many areas of the life sciences. Light refreshments will be served starting at 3 p.m.
Time/Date/Location: 3:30 p.m., Nov. 17, NIMBioS Lecture Hall, 1534 White Ave., Suite 400
Speaker: Dr. Jaewook Joo, UTK Dept. of Physics and Astronomy
Topic:A simple mathematical model for signal processing in macrophages
Abstract: Toll-like receptor 4 (TLR4) senses evolutionarily conserved molecular patterns, lipopolysaccharide (LPS), from the outer membrane of gram-negative bacteria and triggers pro-inflammatory response. This is why our pinky gets swollen within a few hours after it gets cut. Both the key controlling components and their kinetics of the TLR4 signaling pathways are poorly understood. In this talk, I will present a simple mathematical model of an LPS-activated TLR4 signaling network and will attempt to elucidate the underlying mechanisms of the experimentally observed dosage-dependent early innate immune response.