In conjunction with the interdisciplinary activities of the National Institute for Mathematical and Biological Synthesis (NIMBioS), a seminar series on topics in mathematical biology will be hosted at NIMBioS every other Tuesday at 3:30 p.m. (unless otherwise noted) in the Hallam Auditorium, Room 206, Claxton Building, 1122 Volunteer Blvd. Seminar speakers will focus on their research initiatives at the interface of mathematics and many areas of the life sciences. Light refreshments will be served in the 1st floor visitor breakroom beginning 30 minutes before each talk. Faculty and students from across the UT community are welcome to join us.
Time/Date: Tuesday, September 10, 2013, 3:30 p.m.*
Location: Room 105, Claxton Building, 1122 Volunteer Blvd.
Speaker: Dr. Jon Forde, Mathematics and Computer Science, Hobart and William Smith Colleges, and NIMBioS Sabbatical Fellow.
Topic: Modeling the immune reaction to Hepatitis Delta infection
Abstract: Hepatitis Delta Virus (HDV) is a dependent satellite virus of the more common Hepatitis B Virus. HDV encodes only one protein of its own, relying on HBV to supply the additional proteins needed for its replication cycle. Although HDV is noncytotoxic and present few targets for immune reaction, the symptoms of patients with HBV-HDV co-infection are much worse than those infected with HBV alone. The cause of this negative outcome is not clear. This talk presents o.d.e. models for the interaction of HBV, HDV and the antigen-speciﬁc immune responses to explore recovery from T cell exhaustion as a possible explanation of negative outcomes in chronic HBV/HDV co-infection. Additionally, the role of the immune reaction in several other HDV-related phenomena will be discussed, including drug treatment failure and fluctuations in viral load.
*Join us for refreshments at 3 p.m. in the 1st floor visitor breakroom.
Seminar Flyer (pdf)
For more information about this and other NIMBioS Seminars, visit http://www.nimbios.org/seminars.